Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors
Identifieur interne : 001496 ( Main/Exploration ); précédent : 001495; suivant : 001497Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors
Auteurs : H. H. Lee [États-Unis] ; P. Swanson [États-Unis] ; J. D. Rosenblatt [États-Unis] ; I. S. Y. Chen [États-Unis] ; W. C. Sherwood [Afrique du Sud] ; D. E. Smith [États-Unis] ; G. E. Tegtmeier [Royaume-Uni] ; L. P. Fernando [Royaume-Uni] ; C. T. Fang [États-Unis] ; M. Osame [Japon] ; S. H. Kleinman [États-Unis]Source :
- The Lancet [ 0140-6736 ] ; 1991.
English descriptors
- KwdEn :
- Abbott laboratories, Assay, Blood bank, Blood donors, Centre, Chronic leukaemia, Confidence interval, Donor, Donor base, Donor interviews, Endemic regions, Hairy cell leukemia, Healthy controls, High frequency, High rate, Hispanic, Human leukemia virus, Human lymphotropic virus type, Human virus, Infection, Infection rates, Intravenous, Intravenous drug, Intravenous drug abusers, Ivdu, Ivdus, Kansas city, Leukaemia, Leukemia, Neurological disorder, Northern california, Nucleotide, Prevalence, Primer, Primer pair, Primer pairs, Proc natl acad, Risk factors, Routine donor screening, Seropositive, Seropositive donors, Seropositive individuals, Seroprevalence, Seroprevalence rate, Seroprevalence rates, Sexual contacts, Sexual partners, Statistical analysis, University hospital leiden, Volunteer donors, Western blot.
- Teeft :
- Abbott laboratories, Assay, Blood bank, Blood donors, Centre, Chronic leukaemia, Confidence interval, Donor, Donor base, Donor interviews, Endemic regions, Hairy cell leukemia, Healthy controls, High frequency, High rate, Hispanic, Human leukemia virus, Human lymphotropic virus type, Human virus, Infection, Infection rates, Intravenous, Intravenous drug, Intravenous drug abusers, Ivdu, Ivdus, Kansas city, Leukaemia, Leukemia, Neurological disorder, Northern california, Nucleotide, Prevalence, Primer, Primer pair, Primer pairs, Proc natl acad, Risk factors, Routine donor screening, Seropositive, Seropositive donors, Seropositive individuals, Seroprevalence, Seroprevalence rate, Seroprevalence rates, Sexual contacts, Sexual partners, Statistical analysis, University hospital leiden, Volunteer donors, Western blot.
Abstract
The clinical significance of human T-cell lymphotropic virus type II (HTLV-II) infection, unlike that of HTLV-I, is unknown, and the major known association of HTLV-II seropositivity is with intravenous drug abuse. Screening of blood donors for HTLV-I, now routine in North America, does not distinguish this retrovirus from HTLV-II. To find out more about the seroepidemiology of and risk factors for HTLV I and II, blood from 480 000 volunteer donors in five geographically separate US urban centres was tested for antibodies to HTLV-I/II and HIV-1. Confirmed HTLV-I/II seropositive donors were then followed up by DNA amplification to distinguish type I from type II and by interviews focusing on possible risk factors. HTLV seroprevalence was 3·3 times greater than that for HIV-1 (0·043% vs 0·013%). DNA amplification on 65 of the 207 HTLV-I/II seropositive donors revealed that 34 (52%) had HTLV-II infection and 28 (43% had HTLV-I; 3 samples were uninformative. Interviews of 49 donors showed that whereas HTLV-I was principally associated with donor origin from endemic regions, the major risk factor for HTLV-II infection was intravenous drug use. The surprisingly high rate of HTLV-II infection in US blood donors raises important public health and donor counselling issues since HTLV-I infection is associated with adult T-cell leukaemia and a neurological disorder while the pathogenicity of HTLV-II is as yet unclear.
Url:
DOI: 10.1016/0140-6736(91)93126-T
Affiliations:
- Afrique du Sud, Japon, Royaume-Uni, États-Unis
- Californie, Maryland, Pennsylvanie
- Los Angeles, Philadelphie
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000681
- to stream Istex, to step Curation: 000681
- to stream Istex, to step Checkpoint: 000911
- to stream Main, to step Merge: 001629
- to stream Main, to step Curation: 001496
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors</title><author><name sortKey="Lee, H H" sort="Lee, H H" uniqKey="Lee H" first="H. H." last="Lee">H. H. Lee</name></author><author><name sortKey="Swanson, P" sort="Swanson, P" uniqKey="Swanson P" first="P." last="Swanson">P. Swanson</name></author><author><name sortKey="Rosenblatt, J D" sort="Rosenblatt, J D" uniqKey="Rosenblatt J" first="J. D." last="Rosenblatt">J. D. Rosenblatt</name></author><author><name sortKey="Chen, I S Y" sort="Chen, I S Y" uniqKey="Chen I" first="I. S. Y." last="Chen">I. S. Y. Chen</name></author><author><name sortKey="Sherwood, W C" sort="Sherwood, W C" uniqKey="Sherwood W" first="W. C." last="Sherwood">W. C. Sherwood</name></author><author><name sortKey="Smith, D E" sort="Smith, D E" uniqKey="Smith D" first="D. E." last="Smith">D. E. Smith</name></author><author><name sortKey="Tegtmeier, G E" sort="Tegtmeier, G E" uniqKey="Tegtmeier G" first="G. E." last="Tegtmeier">G. E. Tegtmeier</name></author><author><name sortKey="Fernando, L P" sort="Fernando, L P" uniqKey="Fernando L" first="L. P." last="Fernando">L. P. Fernando</name></author><author><name sortKey="Fang, C T" sort="Fang, C T" uniqKey="Fang C" first="C. T." last="Fang">C. T. Fang</name></author><author><name sortKey="Osame, M" sort="Osame, M" uniqKey="Osame M" first="M." last="Osame">M. Osame</name></author><author><name sortKey="Kleinman, S H" sort="Kleinman, S H" uniqKey="Kleinman S" first="S. H." last="Kleinman">S. H. Kleinman</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E4E0EA2DF65635C89E43FC9F3A568C22585306F2</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1016/0140-6736(91)93126-T</idno><idno type="url">https://api.istex.fr/document/E4E0EA2DF65635C89E43FC9F3A568C22585306F2/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000681</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000681</idno><idno type="wicri:Area/Istex/Curation">000681</idno><idno type="wicri:Area/Istex/Checkpoint">000911</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000911</idno><idno type="wicri:doubleKey">0140-6736:1991:Lee H:relative:prevalence:and</idno><idno type="wicri:Area/Main/Merge">001629</idno><idno type="wicri:Area/Main/Curation">001496</idno><idno type="wicri:Area/Main/Exploration">001496</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors</title><author><name sortKey="Lee, H H" sort="Lee, H H" uniqKey="Lee H" first="H. H." last="Lee">H. H. Lee</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Diagnostic Division, Abbott Laboratories, North Chicago</wicri:regionArea><wicri:noRegion>North Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Swanson, P" sort="Swanson, P" uniqKey="Swanson P" first="P." last="Swanson">P. Swanson</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Diagnostic Division, Abbott Laboratories, North Chicago</wicri:regionArea><wicri:noRegion>North Chicago</wicri:noRegion></affiliation></author><author><name sortKey="Rosenblatt, J D" sort="Rosenblatt, J D" uniqKey="Rosenblatt J" first="J. D." last="Rosenblatt">J. D. Rosenblatt</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology-Oncology, Department of Medicine, Jonsson Comprehensive Cancer Center and UCLA School of Medicine, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, I S Y" sort="Chen, I S Y" uniqKey="Chen I" first="I. S. Y." last="Chen">I. S. Y. Chen</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology-Oncology, Department of Medicine, Jonsson Comprehensive Cancer Center and UCLA School of Medicine, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sherwood, W C" sort="Sherwood, W C" uniqKey="Sherwood W" first="W. C." last="Sherwood">W. C. Sherwood</name><affiliation wicri:level="3"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Penn-Jersey Regional Blood Services, American Red Cross, Philadelphia</wicri:regionArea><placeName><settlement type="city">Philadelphie</settlement><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Smith, D E" sort="Smith, D E" uniqKey="Smith D" first="D. E." last="Smith">D. E. Smith</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Blood Center for Southeast Louisiana, Inc, New Orleans</wicri:regionArea><wicri:noRegion>New Orleans</wicri:noRegion></affiliation></author><author><name sortKey="Tegtmeier, G E" sort="Tegtmeier, G E" uniqKey="Tegtmeier G" first="G. E." last="Tegtmeier">G. E. Tegtmeier</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Community Blood Center of Greater Kansas City </wicri:regionArea></affiliation></author><author><name sortKey="Fernando, L P" sort="Fernando, L P" uniqKey="Fernando L" first="L. P." last="Fernando">L. P. Fernando</name><affiliation wicri:level="1"><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Sacramento Medical Foundation Blood Center </wicri:regionArea></affiliation></author><author><name sortKey="Fang, C T" sort="Fang, C T" uniqKey="Fang C" first="C. T." last="Fang">C. T. Fang</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Jerome H. Holland Laboratory, American Red Cross, Rockville, Maryland</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Osame, M" sort="Osame, M" uniqKey="Osame M" first="M." last="Osame">M. Osame</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>IIIrd Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima</wicri:regionArea><wicri:noRegion>Kagoshima</wicri:noRegion></affiliation></author><author><name sortKey="Kleinman, S H" sort="Kleinman, S H" uniqKey="Kleinman S" first="S. H." last="Kleinman">S. H. Kleinman</name><affiliation wicri:level="3"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Los Angeles/Orange Counties Regional Blood Services, American Red Cross, Los Angeles</wicri:regionArea><placeName><settlement type="city">Los Angeles</settlement><region type="state">Californie</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The Lancet</title><title level="j" type="abbrev">LANCET</title><idno type="ISSN">0140-6736</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">337</biblScope><biblScope unit="issue">8755</biblScope><biblScope unit="page" from="1435">1435</biblScope><biblScope unit="page" to="1439">1439</biblScope></imprint><idno type="ISSN">0140-6736</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0140-6736</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbott laboratories</term><term>Assay</term><term>Blood bank</term><term>Blood donors</term><term>Centre</term><term>Chronic leukaemia</term><term>Confidence interval</term><term>Donor</term><term>Donor base</term><term>Donor interviews</term><term>Endemic regions</term><term>Hairy cell leukemia</term><term>Healthy controls</term><term>High frequency</term><term>High rate</term><term>Hispanic</term><term>Human leukemia virus</term><term>Human lymphotropic virus type</term><term>Human virus</term><term>Infection</term><term>Infection rates</term><term>Intravenous</term><term>Intravenous drug</term><term>Intravenous drug abusers</term><term>Ivdu</term><term>Ivdus</term><term>Kansas city</term><term>Leukaemia</term><term>Leukemia</term><term>Neurological disorder</term><term>Northern california</term><term>Nucleotide</term><term>Prevalence</term><term>Primer</term><term>Primer pair</term><term>Primer pairs</term><term>Proc natl acad</term><term>Risk factors</term><term>Routine donor screening</term><term>Seropositive</term><term>Seropositive donors</term><term>Seropositive individuals</term><term>Seroprevalence</term><term>Seroprevalence rate</term><term>Seroprevalence rates</term><term>Sexual contacts</term><term>Sexual partners</term><term>Statistical analysis</term><term>University hospital leiden</term><term>Volunteer donors</term><term>Western blot</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Abbott laboratories</term><term>Assay</term><term>Blood bank</term><term>Blood donors</term><term>Centre</term><term>Chronic leukaemia</term><term>Confidence interval</term><term>Donor</term><term>Donor base</term><term>Donor interviews</term><term>Endemic regions</term><term>Hairy cell leukemia</term><term>Healthy controls</term><term>High frequency</term><term>High rate</term><term>Hispanic</term><term>Human leukemia virus</term><term>Human lymphotropic virus type</term><term>Human virus</term><term>Infection</term><term>Infection rates</term><term>Intravenous</term><term>Intravenous drug</term><term>Intravenous drug abusers</term><term>Ivdu</term><term>Ivdus</term><term>Kansas city</term><term>Leukaemia</term><term>Leukemia</term><term>Neurological disorder</term><term>Northern california</term><term>Nucleotide</term><term>Prevalence</term><term>Primer</term><term>Primer pair</term><term>Primer pairs</term><term>Proc natl acad</term><term>Risk factors</term><term>Routine donor screening</term><term>Seropositive</term><term>Seropositive donors</term><term>Seropositive individuals</term><term>Seroprevalence</term><term>Seroprevalence rate</term><term>Seroprevalence rates</term><term>Sexual contacts</term><term>Sexual partners</term><term>Statistical analysis</term><term>University hospital leiden</term><term>Volunteer donors</term><term>Western blot</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The clinical significance of human T-cell lymphotropic virus type II (HTLV-II) infection, unlike that of HTLV-I, is unknown, and the major known association of HTLV-II seropositivity is with intravenous drug abuse. Screening of blood donors for HTLV-I, now routine in North America, does not distinguish this retrovirus from HTLV-II. To find out more about the seroepidemiology of and risk factors for HTLV I and II, blood from 480 000 volunteer donors in five geographically separate US urban centres was tested for antibodies to HTLV-I/II and HIV-1. Confirmed HTLV-I/II seropositive donors were then followed up by DNA amplification to distinguish type I from type II and by interviews focusing on possible risk factors. HTLV seroprevalence was 3·3 times greater than that for HIV-1 (0·043% vs 0·013%). DNA amplification on 65 of the 207 HTLV-I/II seropositive donors revealed that 34 (52%) had HTLV-II infection and 28 (43% had HTLV-I; 3 samples were uninformative. Interviews of 49 donors showed that whereas HTLV-I was principally associated with donor origin from endemic regions, the major risk factor for HTLV-II infection was intravenous drug use. The surprisingly high rate of HTLV-II infection in US blood donors raises important public health and donor counselling issues since HTLV-I infection is associated with adult T-cell leukaemia and a neurological disorder while the pathogenicity of HTLV-II is as yet unclear.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Japon</li><li>Royaume-Uni</li><li>États-Unis</li></country><region><li>Californie</li><li>Maryland</li><li>Pennsylvanie</li></region><settlement><li>Los Angeles</li><li>Philadelphie</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Lee, H H" sort="Lee, H H" uniqKey="Lee H" first="H. H." last="Lee">H. H. Lee</name></noRegion><name sortKey="Chen, I S Y" sort="Chen, I S Y" uniqKey="Chen I" first="I. S. Y." last="Chen">I. S. Y. Chen</name><name sortKey="Fang, C T" sort="Fang, C T" uniqKey="Fang C" first="C. T." last="Fang">C. T. Fang</name><name sortKey="Kleinman, S H" sort="Kleinman, S H" uniqKey="Kleinman S" first="S. H." last="Kleinman">S. H. Kleinman</name><name sortKey="Rosenblatt, J D" sort="Rosenblatt, J D" uniqKey="Rosenblatt J" first="J. D." last="Rosenblatt">J. D. Rosenblatt</name><name sortKey="Smith, D E" sort="Smith, D E" uniqKey="Smith D" first="D. E." last="Smith">D. E. Smith</name><name sortKey="Swanson, P" sort="Swanson, P" uniqKey="Swanson P" first="P." last="Swanson">P. Swanson</name></country><country name="Afrique du Sud"><region name="Pennsylvanie"><name sortKey="Sherwood, W C" sort="Sherwood, W C" uniqKey="Sherwood W" first="W. C." last="Sherwood">W. C. Sherwood</name></region></country><country name="Royaume-Uni"><noRegion><name sortKey="Tegtmeier, G E" sort="Tegtmeier, G E" uniqKey="Tegtmeier G" first="G. E." last="Tegtmeier">G. E. Tegtmeier</name></noRegion><name sortKey="Fernando, L P" sort="Fernando, L P" uniqKey="Fernando L" first="L. P." last="Fernando">L. P. Fernando</name></country><country name="Japon"><noRegion><name sortKey="Osame, M" sort="Osame, M" uniqKey="Osame M" first="M." last="Osame">M. Osame</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/SidaGhanaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001496 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001496 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= SidaGhanaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:E4E0EA2DF65635C89E43FC9F3A568C22585306F2
|texte= Relative prevalence and risk factors of HTLV-I and HTLV-II infection in US blood donors
}}
| This area was generated with Dilib version V0.6.31. |  |